BiologyMolecular basis of inheritanceClass 12

DNA double helix: interactive simulation

DNA is two strands wound into a right-handed double helix. A always pairs with T using two hydrogen bonds, and G with C using three.

Useful for: NEET, CBSE Boards

Try this

Type your own sequence. The partner strand, hydrogen bond count, GC content, length and mRNA are worked out instantly using the Watson–Crick numbers in NCERT: 0.34 nm per base pair and about 10 base pairs per turn.

  1. 1

    Compare AAAATTTT with GGGGCCCC.

    What you should see

    Both are 8 bp long, but the first has 16 hydrogen bonds and the second has 24. GC-rich DNA is harder to separate.

  2. 2

    Type a 20-base sequence.

    What you should see

    Length = 20 × 0.34 = 6.8 nm, and the helix makes 2 full turns.

  3. 3

    Look at the mRNA line.

    What you should see

    It is complementary to the template strand, with U in place of T.

  4. 4

    Drag to turn the helix.

    What you should see

    The two backbones are not evenly spaced — you can see a wide major groove and a narrow minor groove.

Formulas behind it

Chargaff’s rule

[A]=[T],[G]=[C][A] = [T],\quad [G] = [C]

Hydrogen bonds

H=2(A ⁣− ⁣T pairs)+3(G ⁣− ⁣C pairs)H = 2(A\!-\!T\ \text{pairs}) + 3(G\!-\!C\ \text{pairs})

Length of DNA

L=N×0.34 nmL = N \times 0.34\ \text{nm}

Common mistakes

  • Writing U in DNA. Uracil is found in RNA; DNA has thymine.
  • Giving A–T three hydrogen bonds. It is two; G–C has three.
  • Forgetting that the strands are antiparallel (one runs 5′→3′, the other 3′→5′).
Practise 4 questionsCheck your answer instantly, with a worked solution.Stuck on a dna double helix question?Snap it and get a whiteboard video solution.

FAQ

How long is the DNA in one human cell?

About 6.6 × 10⁹ bp × 0.34 nm ≈ 2.2 m in a diploid cell, as NCERT calculates.

What holds the two strands together?

Hydrogen bonds between paired bases, plus stacking of the bases on top of each other.

Who proposed the double helix?

James Watson and Francis Crick in 1953, using X-ray diffraction data from Rosalind Franklin and Maurice Wilkins.

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